Exchange: Setting Out-of-Office on the Server?

Hi -

I know almost nothing about administering Outlook/Exchange. However, I've been assigned the task of setting up an out-of-office autoreply for a user. I suggested that the user select Tools > Out of Office Assistant (in Outlook) to configure that on her own. She does not have it as an option. I read somewhere that it has to be added to a user's "profile" on the server, but I was unable to determine where that is.

In summary, my question is this: is it possible to assign an autoreply for an individual mailbox on the *server*? If so, could someone nudge me in the right direction?

Thanks in advance.