Sending SMTP Email Through Exchange? (PERL)

Here is my setup:

W2k, IIS
Perl scripts running help desk app
My network is Active Directory
Email system used is Exchange (AD authentication for access)

I have muddled through almost all of the problems I am having trying to figure out how to get the perl script CGIs and PMs to work. The biggest piece is the hardest, though.

I need to have this aplication look into a mailbox we have setup and pull these emails. It also needs to be able to send automated emails.

I feel really stupid because I've been a LAN Admin for about 10 years, but I just cant get this to work. I have PERL modules for POP3 and I should have it configured for SMTP. If I put in the exchange server address in the SMTP address field, I get generic messages why it cannot connect.

Anyone have any ideas? The app is called Trouble Ticket Express ( http://troubleticketexpress.com ) and they have the cgi files on thier website for free if you want to look.

Thanks and please dont laugh if this is really simple. It is really throwing me for a loop.